(5-fluoro-2-pyridinyl)boronic acid

(5-fluoro-2-pyridinyl)boronic acid - Names and Identifiers

Name	5-Fluoropyridine-2-boronic acid
Synonyms	2-Borono-5-fluoropyridine 5-Fluoropyridine-2-boronic acid (5-fluoropyridin-2-yl)boronicaci (5-fluoro-2-pyridinyl)boronic acid B-(5-fluoro-2-pyridinyl)-Boronic acid Boronic acid, B-(5-fluoro-2-pyridinyl)- 5-Fluoropyridine-2-boronic acid5-Fluoropyridine-2-boronic acid
CAS	946002-10-4

(5-fluoro-2-pyridinyl)boronic acid - Physico-chemical Properties

Molecular Formula	C5H5BFNO2
Molar Mass	140.908
Density	1.34
Boling Point	278.7℃
Flash Point	122.3℃
pKa	7.93±0.53(Predicted)
Storage Condition	Inert atmosphere,Store in freezer, under -20°C

(5-fluoro-2-pyridinyl)boronic acid - Introduction

5-Fluoropyridine-2-boronic acid is an organic compound with the chemical formula C5H5BFNO2. Its physical properties include a white to light yellow solid, a melting point of 105-110 degrees Celsius, and solubility in some polar solvents such as alcohols and ketones.

5-Fluoropyridine-2-boronic acid is mainly used as a boronating reagent in organic synthesis reactions. It can undergo nucleophilic reactions with other compounds to form chemical bonds. It is particularly suitable for Suzuki-Miyaura coupling reactions for the construction of carbon-carbon bonds. This reaction is very important for the design and preparation of synthetic natural products, drugs and organic molecules.

The preparation method of 5-Fluoropyridine-2-boronic acid can be achieved by reacting 5-Fluoropyridine-2-boronic acid ester with water or by reacting 5-Fluoropyridine-2-boronic acid sodium with acid.

Regarding safety information, 5-Fluoropyridine-2-boronic acid should be kept away from ignition sources and stored in a sealed container. Wear suitable personal protective equipment such as gloves and goggles during handling and use. It should not be in direct contact with the skin and eyes. Correct laboratory procedures should be followed during handling. If ingested or inhaled by mistake, seek medical attention immediately.

Last Update：2024-04-09 20:02:46